To directly test for an association between
HLA-B*13:01 and the dapsone hypersensitivity
syndrome as well as to assess the accuracy of the
HLA imputation, we determined the HLA-B and
HLA-C alleles in the 39 case patients and 78 controls included in the discovery analysis and an
additional 38 case patients and 206 controls, using
Roche 454 GS FLX sequencing.